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TRAIL, Mouse

TRAIL, Mouse

產(chǎn)品名稱:TRAIL, Mouse

產(chǎn)品貨號(hào):Z03367

規(guī)格:50 μg

價(jià)格:¥ 534

品牌:金斯瑞


SpeciesMouse
Protein Construction

Expressed with an N-terminal Gly.

TRAIL (Arg119-Asn291)
Accession # P50592
Purity> 98% as analyzed by SDS-PAGE
Endotoxin Level< 0.2 EU/μg of protein by gel clotting method
Biological ActivityED50 < 100.0 ng/ml, measured by the cell growth inhibitory assay using RPMI-8226 cells, corresponding to a specific activity of > 1.0 × 104 units/mg.
Expression SystemE. coli
Apparent Molecular Weight~20 kDa, on SDS-PAGE under reducing conditions.
FormulationLyophilized from a 0.2 μm filtered solution in PBS.
ReconstitutionIt is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH?O or PBS up to 100 μg/ml.
Storage & StabilityUpon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.


未標(biāo)題-1.jpg

Target BackgroundTNF-related apoptosis-inducing ligand (TRAIL), also known as Tumor Necrosis Factor Super-Family 10 (TNFSF10) or apoptosis 2 ligand (Apo2L), is a pleiotropic cytokine thatbelongs to the TNF superfamily. Full length TRAIL expressed in vivo is a type II transmembrane protein, although the soluble form also exists and functions. TRAIL has four major receptors: two death receptors DR4 and DR5, and two decoy receptors DcR1 and DcR2. TRAIL binds to the death receptors which recruits the FAS-associated death domain and activates caspases 8 and 10 which eventually leads to apoptosis. Because of its antitumor potential, TRAIL is activelystudied as a therapeutic agent. On the other hand, abnormal expression of TRAIL in small arteries can induce the proliferation of smooth muscle cells, thereby increasing vascular remodeling and pulmonary arterial hypertension.
SynonymsTumor necrosis factor ligand superfamily member 10; TNF-related apoptosis-inducing ligand; Protein TRAIL; CD_antigen: CD253; Tnfsf10


For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.


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